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Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err along the side of caution and permit the FDA do its job and demand some research be done so the public recognizes the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on their medications. Researchers found that participants taking this drug for a year, lost excess weight within 4 weeks and have kept the load off during the entire 56 weeks of the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which can be made up of several active ingredient, which may make them more efficient and safer. Combo-pilling could be the newest fad or better yet the newest to come under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular may be the fact that by right now there are no long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug could also raise blood pressure levels and heartrate, and really should not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must stop used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. 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